
CBFβ Inhibitor
CAS No. 493028-20-9
CBFβ Inhibitor( 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine )
Catalog No. M27517 CAS No. 493028-20-9
CBFβ Inhibitor is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 46 | Get Quote |
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5MG | 70 | Get Quote |
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10MG | 127 | Get Quote |
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25MG | 282 | Get Quote |
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50MG | 385 | Get Quote |
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100MG | 484 | Get Quote |
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200MG | 699 | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameCBFβ Inhibitor
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NoteResearch use only, not for human use.
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Brief DescriptionCBFβ Inhibitor is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.
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DescriptionCBFβ Inhibitor is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.(In Vitro):The ELISA results have shown that CBFβ Inhibitor is very effective in inhibiting the CBFβ-Runx1 interaction (IC50: 3.2 μM). In the leukemia cell line ME-1 expressing CBFβ-SMMHC, CBFβ Inhibitor reduced cell proliferation dose-dependently. Treatment with CBFβ Inhibitor for 3 days showed an increase in apoptotic cells. Treatment with CBFβ Inhibitor for 14 days individually or with all-trans-retinoic acid (ATRA) resulted in cells with greater variation in size and shape, lower nuclear-to-cytoplasmic ratio, increased folding, and lobation of nuclei, and more clumped chromatin. All of these morphology changes are consistent with differentiation to more mature forms. CBFβ Inhibitor at 50 μM increased proliferation of Hep-G2 cells. CBFβ treatment with Inhibitor resulted in a statistically significant reduction in Runx1 bound to DNA .
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In Vitro——
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In Vivo——
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Synonyms5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorCleavable
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Research Area——
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Indication——
Chemical Information
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CAS Number493028-20-9
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Formula Weight234.32
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Molecular FormulaC12H14N2OS
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Purity>98% (HPLC)
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Solubility——
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SMILESCCc1sc(N)nc1-c1ccc(OC)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
molnova catalog



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